<i>Helicobacter pylori</i> activates histone lactylation to promote gastric cancer progression and immune evasion through the HAS2/c-MYC/PD-L1 axis

BACKGROUND: )-associated GC progression remains largely elusive. METHODS: mouse xenograft models were employed in this study. Clinical GC tissue cohorts were analyzed to validate the clinical relevance of the identified signaling pathways. The epigenetic and immunological impacts of lactate metabolism were assessed using glycolysis inhibitors (2-DG and oxamate) and genetic silencing of LDHA and LDHB. RESULTS: T-cell infiltration and exerted robust antitumor efficacy. CONCLUSIONS: -associated disease.