Signals in space: TGF-β defines where and what gut macrophages become
Macrophages are profoundly shaped by their tissue of residence. In this issue, Jayaraman et al. (https://doi.org/10.1084/jem.20240801) show that TGF-β signaling is crucial for maintaining the identity, function, and spatial organization of long-lived intestinal macrophages, highlighting an essential component of the gut niche.
Authors
- Camille Blériot (ORCID: https://orcid.org/0000-0002-4298-2888)
- Florent Ginhoux (ORCID: https://orcid.org/0000-0002-2857-7755)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Shanghai Jiao Tong University (CN)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Singapore Immunology Network (SG)
- Institut Gustave Roussy (FR)
- Institut Necker Enfants Malades (FR)
- Institute of Natural Science (KP)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1084/jem.20260402
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Fondation ARC pour la Recherche sur le Cancer
- Fondation Gustave Roussy