Quantitative assessment of CD79B depletion as a biomarker of accelerated B cell progenitor aging
lymphoid progenitors in bone marrow from aged mice and accelerated aging models, phenocopying advanced physiological aging in humans. Thus, this detailed protocol provides a validated platform to interrogate novel biomarkers of hematopoietic stem and progenitor cell dysfunction associated with systemic aging.
Authors
- Dorota Skowronska‐Krawczyk (ORCID: https://orcid.org/0000-0002-5758-4225)
- Leslie Crews (ORCID: https://orcid.org/0000-0003-0704-0067)
- Silvia Vicenzi (ORCID: https://orcid.org/0000-0001-5670-7169)
- H A. Kim
- Rosslyn Farnan
Institutions
- University of California, Irvine (US)
- University of California San Diego (US)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1016/j.scr.2026.103993
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- California Institute for Regenerative Medicine
- American Society of Hematology
- International Waldenstrom's Macroglobulinemia Foundation
- International Myeloma Foundation
- Leukemia and Lymphoma Society
- National Cancer Institute