Spatially Compartmentalized DNA Nanodevices for Extra-/Intracellularly Synergistically Modulating Cancer Cell Behaviors
-induced G-quadruplex dimerization promotes the proximity of transferrin receptor (TfR) aptamers to activate TfR-mediated doxorubicin (DOX) delivery. The GA-Tc/DOX nanodevice significantly suppresses the proliferative and migratory capabilities of cancer cells through synergistic membrane-intracellular modulation, thus establishing a paradigm for spatially regulated cancer cell intervention and offering a sophisticated tool for advancing precision therapeutics.
Authors
- X.C. Li (ORCID: https://orcid.org/0000-0002-5981-2762)
- Lili Shi (ORCID: https://orcid.org/0000-0001-7938-1907)
- Ruixue Chang (ORCID: https://orcid.org/0000-0001-9382-9667)
- T F Li
- Yanjun Liu (ORCID: https://orcid.org/0009-0001-6872-8204)
- Tao Huang
Institutions
- University of Science and Technology of China (CN)
- Anhui University (CN)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acsabm.6c00422
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China