Genome-wide association study of myopia progression in Chinese adolescents and application of polygenic risk score prediction
: 5.69%; OR: 1.61, 95% CI: 1.06-2.44; AUC: 0.66) outperformed both the European and cross-ancestry datasets. This study identified seven promising loci associated with myopia progression and demonstrated that PRS exhibited enhanced predictive performance in genetically and phenotypically matched populations. Our findings expand the genetic understanding of myopia progression in East Asian adolescents and provide new insights for myopia prevention and control.
Authors
- Yingyun Shi
- Mike Z. He (ORCID: https://orcid.org/0000-0003-2357-3883)
- Hui Shen (ORCID: https://orcid.org/0000-0003-4009-2598)
- Wei Yizhou
- Wei Xiaoyu
- Liu Chengyong
- Liu Qinye
- Jia Hu
- Xinglun Dang
- Fen Chen
- Di Han
- Weina Liu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Southeast University (BD)
- Zhongda Hospital Southeast University (CN)
- Taiwan Centers for Disease Control (TW)
- Nanjing Medical University (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3389/fchem.2026.1778732
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Southeast University