CACA guidelines for managing cancer therapy-induced neutropenia (2026)
Abstract Anticancer therapy, encompassing systemic therapies such as chemotherapy, targeted therapy, and immunotherapy, as well as radiotherapy, can induce neutropenia. This condition is a frequent hematological adverse event and a dose-limiting toxicity. Neutropenia can cause interruptions or delays in anticancer therapy, febrile neutropenia, and serious infections, which in turn raises treatment costs, reduces therapeutic efficacy, and may even lead to life-threatening complications. Consequently, accurately assessing the risk of neutropenia, promptly identifying febrile neutropenia and infections, and implementing appropriate preventive and therapeutic measures are crucial for mitigating anticancer therapy-related complications, enhancing the safety and effectiveness of anticancer therapy. Grounded in evidence-based medicine and expert consensus, the Committee of Neoplastic Supportive-Care (CONS) of the China Anti-Cancer Association has developed these guidelines to assist clinical oncologists in managing neutropenia resulting from anticancer therapy.
Authors
- Jun Zhang (ORCID: https://orcid.org/0000-0002-7973-8416)
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Wenxing Qin
- Li Xiao
- Ying Yuan
- Xianglin Yuan
- Shu Xia
- Yi Ba
- Yanhong Deng
Institutions
- Zhejiang Chinese Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Ruijin Hospital (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Peking University Cancer Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Holistic Integrative Oncology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1007/s44178-026-00234-3
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Major Program of National Fund of Philosophy and Social Science of China