LVAD Therapy Improves Metabolic and Inflammatory State in the Heart
Left ventricular assist devices remain a major step forward for end-stage heart failure patients awaiting transplantation. We investigated the molecular basis of the longitudinal effect of left ventricular assist device implantation in both ischemic and nonischemic cardiomyopathy patients. The results revealed a common signature of 13 genes associated with glucocorticoid receptor overexpression pretransplantation, independent of the etiology. Four key molecular hub genes from this signature were highlighted, involved respectively in metabolic plasticity (PDK4), limited inflammation (FKBP5 and ZBTB16), and repair (FOXO3). It shows, however, that these pathways contribute to cardiac homeostasis.
Authors
- Anique Ducharme (ORCID: https://orcid.org/0000-0003-1681-9187)
- Filio Billia (ORCID: https://orcid.org/0000-0002-2824-1215)
- Éric Thorin (ORCID: https://orcid.org/0000-0001-5827-8935)
- Olina Dagher (ORCID: https://orcid.org/0000-0002-2010-7177)
- Pauline Mury (ORCID: https://orcid.org/0000-0001-5202-7078)
- Shreya Gramolini
- Pierre-Emmanuel Noly
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Montreal Heart Institute (CA)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1016/j.jacbts.2026.101540
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé