Asymmetric Xanthene with Noncovalent Conformation Locks to Attain High Fluorescence >1500 nm
was further prepared as polymer dots (Pdots) for high-contrast, deep-tissue vascular imaging and AI-assisted resolution of hindlimb vasculature. This study provides a synthetically versatile and structurally diverse platform for NIR-IIb fluorophores, demonstrating that asymmetric donor-acceptor-donor scaffolds coupled with polymer-mediated geometry control can simultaneously optimize the emission wavelength and brightness.
Authors
- Syue-Liang Lin (ORCID: https://orcid.org/0000-0003-3134-9304)
- Y J Chan
- Ričardas Rotomskis (ORCID: https://orcid.org/0000-0003-0825-4884)
- T N Wu
- Yu‐Fen Huang (ORCID: https://orcid.org/0000-0001-7686-8090)
- Simona Steponkienė (ORCID: https://orcid.org/0000-0002-3469-0543)
- Chao‐Ping Hsu (ORCID: https://orcid.org/0000-0002-7187-427X)
- Yen‐Chang Chen
- Hsin-Ting Huang
- Hsiu‐Feng Lu
- Meng‐Huan Liu
- Kai-Min Chan
- Partha Chowdhury
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- National Tsing Hua University (TW)
- Biotechnology Research Center (IR)
- Bioscience (China) (CN)
- RIKEN Center for Emergent Matter Science (JP)
- National Cancer Institute (LT)
- Academia Sinica (TW)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/jacs.5c23313
- Primary Topic
- Synthesis and Properties of Aromatic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academia Sinica
- Lietuvos Mokslo Taryba
- National Chiao Tung University
- National Science and Technology Council