Plaque-Type Psoriasis Induced by Non-Steroidal Aromatase Inhibitor (Letrozole): A Case Series

Psoriasis is a multifactorial disease triggered by various factors, including medications. Letrozole is an effective adjuvant hormonal therapy used in the treatment of breast cancer and has been linked to different skin eruptions. However, psoriasis is not a well-established side effect. We describe two patients with similar manifestations of plaque psoriasis. Both cases were confirmed through histological examination. This case report highlights the importance of recognizing letrozole as a possible cause of plaque psoriasis.

Authors

Publication Details

Journal
Cureus
Published
2026-04-21
DOI
https://doi.org/10.7759/cureus.107454
Primary Topic
Psoriasis: Treatment and Pathogenesis
Type
article
Field-Weighted Citation Impact
0.00
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article

Plaque-Type Psoriasis Induced by Non-Steroidal Aromatase Inhibitor (Letrozole): A Case Series

Lenah Y. Shaikh, Gaeda Khaled I Alkaltham, Musaed Alsebayel, Amnah Nasser Almulhim
Cureus
Psoriasis: Treatment and Pathogenesis
article

Plaque-Type Psoriasis Induced by Non-Steroidal Aromatase Inhibitor (Letrozole): A Case Series

Lenah Y. Shaikh, Gaeda Khaled I Alkaltham, Musaed Alsebayel, Amnah Nasser Almulhim
article en

Abstract

Psoriasis is a multifactorial disease triggered by various factors, including medications. Letrozole is an effective adjuvant hormonal therapy used in the treatment of breast cancer and has been linked to different skin eruptions. However, psoriasis is not a well-established side effect. We describe two patients with similar manifestations of plaque psoriasis. Both cases were confirmed through histological examination. This case report highlights the importance of recognizing letrozole as a possible cause of plaque psoriasis.

Cureus
Good health and well-being
Openalex Percentile: Top 9%
Psoriasis: Treatment and Pathogenesis
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Plaque-Type Psoriasis Induced by Non-Steroidal Aromatase Inhibitor (Letrozole): A Case Series — Lenah Y. Shaikh, Gaeda Khaled I Alkaltham, et al. · Cureus (2026) | TGRS Research Map | TGRS