Periodontitis and Pancreatic Cancer Risk: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
: Observational evidence suggests a modest statistical association between periodontitis and pancreatic cancer risk. However, the absolute risk increase is very small, and Trial Sequential Analysis indicates that cumulative evidence remains insufficient to establish causality or to support preventive or clinical recommendations. Further large-scale prospective studies with standardized periodontal assessments are required.
Authors
- Carlos Enrique Cuevas‐Suárez (ORCID: https://orcid.org/0000-0002-2759-8984)
- Abigailt Flores‐Ledesma (ORCID: https://orcid.org/0000-0002-8136-4820)
- Andrea Ordóñez Balladares (ORCID: https://orcid.org/0000-0002-6559-4597)
- Luis Chauca-Bajaña (ORCID: https://orcid.org/0000-0002-8713-951X)
- Kareelend Andreina Segura Cueva (ORCID: https://orcid.org/0000-0002-3437-3548)
- Andrea Bermúdez Velásquez
- Carlos Andrés Guim Martínez
- Byron Velasquez Ron
- Leonardo Javier Siguencia Suárez
- Alejandro Ismael Lorenzo-Pouso (ORCID: https://orcid.org/0000-0002-9180-4703)
Institutions
- Universidad Autónoma del Estado de Hidalgo (MX)
- Central University of Ecuador (EC)
- Universidade de Santiago de Compostela (ES)
- University of Guayaquil (EC)
- Universidad Católica de Santiago de Guayaquil (EC)
- Universidad de Las Américas (EC)
- Benemérita Universidad Autónoma de Puebla (MX)
Publication Details
- Journal
- Journal of Clinical Medicine
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/jcm15083154
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00