Modulatory Effects of Bioactive Phytoconstituents on the Amplitude and Gating Properties of Membrane Ion Channels
, potentially contributing to both therapeutic efficacy and adverse effects. Collectively, the compound-specific modulation of current amplitude and gating kinetics offers valuable mechanistic insight into the pharmacological and toxicological significance of plant-derived natural products, highlighting the functional role of ion channel evaluation in guiding their therapeutic development and ensuring safety assessment.
Authors
- Sheng‐Nan Wu (ORCID: https://orcid.org/0000-0002-5208-3253)
- Guglielmina Froldi (ORCID: https://orcid.org/0000-0002-5936-1789)
- Ya‐Jean Wang (ORCID: https://orcid.org/0000-0002-7524-4363)
- Rasa Liutkevičienė
Institutions
- Lithuanian University of Health Sciences (LT)
- University of Padua (IT)
- Minghsin University of Science and Technology (TW)
- China Medical University (TW)
- An-Nan Hospital (TW)
Publication Details
- Journal
- Molecules
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/molecules31081360
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology, Taiwan
- Tainan Municipal An-Nan Hospital