Rapid and Specific Detection of Gastric Cancer EVs Using a Cas12a-Powered Aptasensor with a Novel Targeting Aptamer
-cleavage of a fluorescent reporter, producing a quantifiable signal. This aptasensor facilitates the rapid, highly sensitive, and specific detection of gastric cancer EVs, presenting a promising platform for the development of noninvasive, point-of-care early diagnostic tools.
Authors
- Yunfeng Zai (ORCID: https://orcid.org/0000-0001-6021-4367)
- Z Li
- Gaojian Yang
- Yile Fang (ORCID: https://orcid.org/0000-0003-0171-8818)
- Ahmad M. Umar Siddiqui
- Libo Nie
- Yuan Liu
- Enben Su
- Zhu Chen
- Nongyue He (ORCID: https://orcid.org/0000-0002-5826-5752)
- Song Li
- Yan Deng
Institutions
- Digital Science (United States) (US)
- Nanjing Drum Tower Hospital (CN)
- Kai Biotech (South Korea) (KR)
- State Key Laboratory of Digital Medical Engineering (CN)
- Najran University (SA)
- Hunan University of Technology (CN)
- The Ohio State University (US)
- Nanjing University (CN)
- University of South China (CN)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.analchem.5c08039
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00