Correlation analysis and diagnostic performance of CT/MRI fat quantification parameters in metabolic dysfunction–associated steatotic liver disease

Introduction: Early quantitative diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) is crucial for preventing disease progression. Fat analysis and calculation technique (FACT) MRI fat quantification has shown potential diagnostic value. This study aimed to compare the diagnostic performance of CT and MRI fat quantification techniques and to evaluate their correlation with clinical and biochemical markers in in patients with MASLD. Methods: = 99) for diagnostic performance evaluation. Diagnostic performance was evaluated using ROC curves and AUC values, with the DeLong tests used for pairwise comparisons. Results: . CT parameters demonstrated acceptable but lower diagnostic performance diagnostic performance than MRI parameters. Conclusion: ) should be interpreted with caution. FACT-derived fat parameters showed significant correlations with CT-based measures and serum markers and demonstrated higher diagnostic performance compared to CT-based parameters. These findings suggest FACT-derived MRI parameters may serve as useful non-invasive tools for assessing hepatic fat content in MASLD. However, further validation with accurate reference standards, such as MRI-PDFF or liver biopsy, is required to confirm their clinical utility.