A Standardized Onion Peel-Derived Bioactive Ingredient Attenuates Palmitate-Induced Steatosis and Oxidative Stress by Modulating Mitochondrial Dynamics and Autophagy in HepG2 Cells
variety showed weaker or inconsistent effects under the same experimental conditions. Overall, these findings support the functional validation of a standardized onion peel-derived ingredient, highlighting its potential application as a bioactive component for functional food or nutraceutical development targeting hepatic steatosis and oxidative stress.
Authors
- Luca Rastrelli (ORCID: https://orcid.org/0000-0003-0718-5450)
- Anna Lisa Piccinelli (ORCID: https://orcid.org/0000-0001-6102-2762)
- Vincenzo Migliaccio (ORCID: https://orcid.org/0000-0002-8820-4694)
- Mariateresa Russo (ORCID: https://orcid.org/0000-0002-5159-588X)
- Lillà Lionetti (ORCID: https://orcid.org/0000-0002-4059-8030)
- Di Gregorio (ORCID: https://orcid.org/0000-0001-5521-1970)
- Rita Celano (ORCID: https://orcid.org/0000-0002-6357-594X)
- Maria D’Elia (ORCID: https://orcid.org/0009-0009-5315-3055)
- V Santoro
Institutions
- University of Salerno (IT)
- University of Reggio Calabria (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Antioxidants
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/antiox15040513
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00