Activation of Synergistic Ferroptosis and Apoptosis by a Cu(II) Complex through Concurrent Amplification of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction
demonstrates significant antitumor and antimetastatic efficacy in a cervical cancer model, with minimal systemic toxicity and desirable biocompatibility. This work highlights the innovative use of copper-based complexes to manipulate organelle communication networks precisely, providing a new paradigm for metal-based anticancer agents.
Authors
- Huichao Lin (ORCID: https://orcid.org/0000-0001-8260-1763)
- M. Iqbal Choudhary (ORCID: https://orcid.org/0000-0001-5356-3585)
- Hai-Qun Zhang
- Yang-Han Liu
- Fang‐Xin Wang (ORCID: https://orcid.org/0000-0002-7981-2495)
- Zhen-Feng Chen (ORCID: https://orcid.org/0000-0002-6548-6131)
- Hong Liang (ORCID: https://orcid.org/0000-0001-6131-7181)
- Li-Fang Cen
Institutions
- University of Karachi (PK)
- Ministry of Natural Resources (CN)
- Guangxi Normal University (CN)
- International Center for Chemical and Biological Sciences (PK)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00141
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00