Comparative Pharmacological Profiling of Psychotherapeutic Drugs Reveals a Functional Taxonomy Based on Direct Inhibition of Smooth Muscle Excitability
This study reveals a previously underrecognized pharmacodynamic dimension of psychotherapeutic drugs and establishes a comparative functional taxonomy based on their direct, non-receptor-mediated inhibition of smooth muscle excitability. The identified profiles provide a mechanism-informed framework for contextualizing autonomic side-effect liability and may support improved safety evaluation in psychotherapeutic drug development.
Authors
- Manuel Garrosa
- Diego Fernández‐Lázaro (ORCID: https://orcid.org/0000-0002-6522-8896)
- Jesús Pérez
- Alfonso Velasco
- Juan F. Mielgo-Ayuso
- Carlos Alberto Rodríguez-Arias
- María Jesús Castrillejo (ORCID: https://orcid.org/0009-0004-5075-7658)
Institutions
- Universidad de Valladolid (ES)
- Universidad de Salamanca (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Hospital Clínico Universitario de Valladolid (ES)
- Hospital Universitario de León (ES)
- Universidad de Burgos (ES)
- Universidad de León (ES)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/ph19040645
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- Universidad de Valladolid
- Consejería de Educación, Junta de Castilla y León
- Junta de Castilla y León