Transcription Factor–Mediated Reprogramming of Cancer-Associated Fibroblasts Reveals Targetable Vulnerabilities in Solid Tumors
, VDR-rpNFs disrupted tumor architecture, enhanced CAR T cell infiltration, and reduced necrosis. PPARγ- and p53-rpNFs showed similar reprogramming effects. These results suggest TF-guided fibroblast reprogramming as a viable strategy to remodel the tumor microenvironment and improve CAR T cell efficacy in solid tumors.
Authors
- Yixuan Huang (ORCID: https://orcid.org/0000-0003-1679-8435)
- Sreejesh Moolayadukkam (ORCID: https://orcid.org/0000-0002-1046-447X)
- Priyankan Datta (ORCID: https://orcid.org/0000-0002-2899-6714)
- Tianze Guo
- Ishwar K. Puri (ORCID: https://orcid.org/0000-0002-8713-4188)
- Bella Raykowski
- Xi Yu (ORCID: https://orcid.org/0009-0004-5003-7298)
- Shigang Xiong
- Jacek Pinski
- Nan Sook Lee
- Chi Woo Yoon
- Christopher DeRenzo
- Yingxiao Wang (ORCID: https://orcid.org/0000-0003-0265-326X)
- Peixiang He
Institutions
- University of Southern California (US)
- Translational Genomics Research Institute (US)
- St. Jude Children's Research Hospital (US)
- Alfred Mann Foundation (US)
- USC Norris Comprehensive Cancer Center (US)
- Brigham Young University - Idaho (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-20
- DOI
- https://doi.org/10.64898/2026.04.15.718753
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00