Sex as a Contextual Modifier in Colorectal Cancer: Integrating Tumor Sidedness, Molecular Subtype, Immune Ecology, and Early-Onset Disease
-mutated metastatic CRC, and early-onset CRC. A sex-aware, subtype-aware, and location-aware framework therefore offers a more clinically useful interpretation of CRC heterogeneity than descriptive male-versus-female comparisons alone.
Authors
- Dongming Xing (ORCID: https://orcid.org/0000-0002-2359-0440)
- Xinlin Liu (ORCID: https://orcid.org/0000-0002-6311-8984)
- Bing Liang
- Tingting Zhang
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/cancers18081309
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00