Evidence Map for Human Restoration Theory Mechanobiology, Load Path Economics, and the Structural Conditions of Chronic Dysfunction

Abstract Human Restoration Theory proposes that skeletal load-bearing efficiency under gravity functions as a systemic regulatory variable influencing muscular recruitment, respiratory mechanics, autonomic regulation, fluid exchange, and long-term tissue adaptation. For such a framework to be meaningful, it must not stand as an isolated conceptual claim, but as an integrative structure capable of organizing existing evidence across multiple scientific domains. This paper presents an evidence map linking the framework to converging lines of research in mechanotransduction, trabecular bone adaptation, fascial continuity, anticipatory postural control, autonomic load regulation, chronic pain distribution, and developmental biomechanics. The aim is not to claim direct proof of the model, but to identify where independent observations across disciplines suggest that load path, structural transmission, and mechanical economy may have broader regulatory significance than commonly assumed. Rather than proposing a new therapy, the framework functions as an infrastructural hypothesis: that chronic dysfunction often reflects life under persistently expensive organizational conditions. The question is therefore shifted from isolated pathology toward the mechanical and developmental conditions that make compensation necessary.