A New Series of Amino Alcohol Oxime Ethers as Activators of Human Brain Carbonic Anhydrases: Advances in Selective Activation of Human Carbonic Anhydrase VII
= 72 nM) and selective over other brain isoforms. These results were further supported by in silico studies, which revealed favorable binding interactions at site A due to structural features present in both R and S enantiomers of compound 12.
Authors
- Sabrina Taliani (ORCID: https://orcid.org/0000-0001-8675-939X)
- Riccardo Di Leo (ORCID: https://orcid.org/0000-0002-5051-1584)
- Alessio Nocentini (ORCID: https://orcid.org/0000-0003-3342-702X)
- Claudiu T. Supuran (ORCID: https://orcid.org/0000-0003-4262-0323)
- Paola Gratteri (ORCID: https://orcid.org/0000-0002-9137-2509)
- Elisa Nuti (ORCID: https://orcid.org/0000-0003-2669-5376)
- Doretta Cuffaro (ORCID: https://orcid.org/0000-0002-8842-542X)
- Armando Rossello (ORCID: https://orcid.org/0000-0002-6795-8091)
- Jacopo Castagnoli
- Camilla Mangini
Institutions
- University of Pisa (IT)
- Istituto di Fisiologia Clinica (IT)
- National Research Council (IT)
- University of Florence (IT)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1002/cmdc.70272
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università di Pisa