Neurotoxic and Metabolic Effects of Chronic Aspartame Consumption in Rodent Models: A Systematic Review and Meta-Analysis

= 85.4%) and a lack of detailed reporting in primary studies, resulting in uncertain internal validity across several risk-of-bias domains. While these results provide a critical signal regarding the neurotoxic and metabolic potential of aspartame, they underscore the urgent need for improved reporting standards in preclinical toxicology and long-term human epidemiological studies to fully clarify its safety profile.