Aging and DNA damage are associated with the development of endothelial cell clonal expansion
These findings suggest that clonal expansion is promoted by both aging and DNA damage. Clonal expansion may represent an underrecognized mechanism contributing to endothelial homogeneity and vascular remodeling during aging and in response to sub-lethal genomic stress.
Authors
- Arthur José Pontes Oliveira de Almeida (ORCID: https://orcid.org/0000-0003-2501-3249)
- Hossein Abdeahad (ORCID: https://orcid.org/0000-0002-8021-5516)
- Anthony J. Donato (ORCID: https://orcid.org/0000-0002-2548-772X)
- Denisse G Moreno
- Lisa A. Lesniewski (ORCID: https://orcid.org/0000-0002-2138-1450)
- Larisse Virgolino da Silva Pontes
Institutions
- University of Utah (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- American Journal of Physiology-Heart and Circulatory Physiology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1152/ajpheart.00102.2026
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nora Eccles Treadwell Foundation
- National Institute on Aging
- Veterans Affairs Scholarship Program