A multi-omics study of the efficacy and safety of menopausal hormone therapy and its effect on coexisting microecology in humans

The overall goal of this project is to accumulate valuable data on Chinese perimenopausal women by establishing a clinical cohort. On the one hand, we will observe the natural change pattern of female reproductive aging and explore its typical features; on the other hand, we will evaluate the effectiveness and safety of MHT in Chinese women's menopausal diseases, and gain an in-depth understanding of the mechanism of MHT's action on women's menopausal diseases.