Mast cell release of TNF-α indirectly contributes to recalling B cells in the colorectal cancer milieu through the CCL20/CCR6 axis
Introduction: In colorectal cancer (CRC), mast cells (MCs) modulate tumor and immune cell interactions, influencing patient prognosis, though their role remains not fully elucidated. Our group previously uncovered that in the intestine MCs provide support for the effector functions of B cells, both in physiology and inflammation. Methods: In this work we investigated the relationship between the activation of MCs in CRC and recruitment and accumulation of B cells in the tumor environment. Results: . Discussion: B cells in CRC context may then rely on the crosstalk between MCs and CRC cells. Our findings suggest that B cell immunosurveillance may be indirectly promoted through the clinical modulation of TNF-α secretion at the early stages of colorectal tumorigenesis.
Authors
- Viviana Valeri
- Laura Mariuzzi (ORCID: https://orcid.org/0000-0002-1243-8398)
- Barbara Frossi (ORCID: https://orcid.org/0000-0001-9855-2396)
- Eleonora Martinis (ORCID: https://orcid.org/0000-0002-2667-6530)
- Francesca Mion
- Marta Mozzon (ORCID: https://orcid.org/0000-0002-9690-5175)
- Elena Jachetti (ORCID: https://orcid.org/0000-0001-6483-7350)
- Alessandro Uzzau (ORCID: https://orcid.org/0000-0001-6375-9995)
- Silvia Tonon (ORCID: https://orcid.org/0000-0002-3361-2906)
- Serena Battista (ORCID: https://orcid.org/0000-0002-8191-0131)
- Beatrice Belmonte (ORCID: https://orcid.org/0000-0001-9668-0925)
- Roberta Sulsenti (ORCID: https://orcid.org/0000-0002-2247-056X)
- Valeria Cancila (ORCID: https://orcid.org/0000-0002-9502-1191)
- Marco Fontanot
- Claudio Tripodo (ORCID: https://orcid.org/0000-0002-0821-6231)
- Alessandro Mangogna (ORCID: https://orcid.org/0000-0001-7910-1274)
- Eleonora Capezzali
- Carlo Pucillo
Institutions
- University of Udine (IT)
- University of Trieste (IT)
- University of Milan (IT)
- IFOM (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- University of Palermo (AR)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Misericordia University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3389/fimmu.2026.1725902
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00