TRIP8b <sub>nano</sub> peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain
reduces mechanical and thermal hypersensitivity in a rat model of neuropathic pain. Our findings confirm a direct role of cAMP-HCN2 signalling in neuropathic pain and suggest a new therapeutic target.
Authors
- Andrea Saponaro (ORCID: https://orcid.org/0000-0001-5035-5174)
- Rajesh Khanna (ORCID: https://orcid.org/0000-0002-9066-2969)
- Gerhard Thiel (ORCID: https://orcid.org/0000-0002-2335-1351)
- Santiago Loya‐López (ORCID: https://orcid.org/0000-0001-6207-8370)
- Kimberly Gómez (ORCID: https://orcid.org/0000-0003-1867-5041)
- Heather N. Allen (ORCID: https://orcid.org/0000-0003-0771-1959)
- Anna Moroni (ORCID: https://orcid.org/0000-0002-1860-406X)
- A Guariglia F Porro
Institutions
- University of Milan (IT)
- University of Florida (US)
- Capricor Therapeutics (United States) (US)
Publication Details
- Journal
- The Journal of Physiology
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1113/jp290260
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Milano
- Fondazione Telethon
- Fondazione Cariplo