Human Gut Microbiome Can Degrade the Sweetener Acesulfame K with Potential Damaging Effects in the Intestinal Barrier Function
can metabolize to produce butyrate via the butanoyl-CoA pathway. Furthermore, the Ace-K-microbiome interaction led to a dose-dependent decrease in Caco-2 epithelial integrity, possibly due to the release of sulfated metabolites. This study provides evidence of the potential risk of Ace-K consumption based on its metabolism by the human gut microbiome.
Authors
- Teresa Requena (ORCID: https://orcid.org/0000-0002-8846-6846)
- M. Carmen Martínez‐Cuesta (ORCID: https://orcid.org/0000-0001-9618-2571)
- Alicia Bellanco (ORCID: https://orcid.org/0000-0003-4995-2929)
- Marta Lozano
- Cristina Yépez-Notario
Institutions
- Instituto de Productos Lácteos de Asturias (ES)
- Instituto de Investigación en Ciencias de la Alimentación (ES)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.jafc.5c16498
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Superior de Investigaciones Científicas
- Agencia Estatal de Investigación