Discovery, Synthesis of Myrtucommulone B Analogs as Soluble Epoxide Hydrolase Inhibitors and Their Biological Activities

mechanism involves elevating anti-inflammatory epoxyeicosatrienoic acids (EETs) and reducing proinflammatory dihydroxyeicosatrienoic acids (DHETs) by blocking sEH, thereby suppressing proinflammatory cytokines (TNF-α, IL-6). This study lays a foundation for developing myrtucommulone-based sEH inhibitors as novel anti-inflammatory/analgesic agents, particularly potential therapeutics for AP.

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Publication Details

Journal
Journal of Medicinal Chemistry
Published
2026-04-21
DOI
https://doi.org/10.1021/acs.jmedchem.5c03313
Primary Topic
Eicosanoids and Hypertension Pharmacology
Type
article
Field-Weighted Citation Impact
0.00

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article

Discovery, Synthesis of Myrtucommulone B Analogs as Soluble Epoxide Hydrolase Inhibitors and Their Biological Activities

Yu Zhang, Kang Shuang-shuang, Bolin Wang, Yang X et al.
Journal of Medicinal Chemistry
Eicosanoids and Hypertension Pharmacology
article

Discovery, Synthesis of Myrtucommulone B Analogs as Soluble Epoxide Hydrolase Inhibitors and Their Biological Activities

Yu Zhang, Kang Shuang-shuang, Bolin Wang, Yang X, Jia-Rui Sun
article en

Abstract

mechanism involves elevating anti-inflammatory epoxyeicosatrienoic acids (EETs) and reducing proinflammatory dihydroxyeicosatrienoic acids (DHETs) by blocking sEH, thereby suppressing proinflammatory cytokines (TNF-α, IL-6). This study lays a foundation for developing myrtucommulone-based sEH inhibitors as novel anti-inflammatory/analgesic agents, particularly potential therapeutics for AP.

Journal of Medicinal Chemistry
Henan Academy of Agricultural Sciences (CN), ZheJiang Academy of Agricultural Sciences (CN), Hengyang Academy of Agricultural Sciences (CN), University of South China (CN)
Education Department of Hunan Province, Natural Science Foundation of Hunan Province
Openalex Percentile: Top 11%
Eicosanoids and Hypertension Pharmacology
DOISourceOpenAlex
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