Sensory neurons inhibit invadopodia and metastasis via direct CGRP-RAMP1-cAMP signaling to cancer cells
findings, we compare RAMP1 expression in the patient breast tumors with adjacent normal tissues, confirming the invasive breast tumors have reduced levels of RAMP1. Together, our findings identify a protective role for the paracrine CGRP signaling in limiting breast cancer invasion and metastasis. We also demonstrate how cancer cells circumvent CGRP inhibition by suppressing RAMP1 expression, highlighting CGRP-RAMP1-cAMP axis as a potential therapeutic target in breast cancer.
Authors
- Débora B. Vendramini‐Costa (ORCID: https://orcid.org/0000-0001-7617-4945)
- Bojana Gligorijevic (ORCID: https://orcid.org/0000-0001-9071-7467)
- Edna Cukierman (ORCID: https://orcid.org/0000-0002-1452-9576)
- Louis Hodgson (ORCID: https://orcid.org/0000-0001-9188-7580)
- Ralph Francescone (ORCID: https://orcid.org/0000-0002-3149-6825)
- Maíra A. Lima (ORCID: https://orcid.org/0000-0002-2402-3085)
- Ines Velazquez Quesada
- Afrooz Jarrah
- Elizaveta Belova
- Maria Carolina Cesar Mariano
- Yasmine Dahleh
Institutions
- Fox Chase Cancer Center (US)
- Albert Einstein College of Medicine (US)
- Henry Ford Health System (US)
- Wayne State University (US)
- Henry Ford Hospital (US)
- Temple University (US)
- Michigan State University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-21
- DOI
- https://doi.org/10.64898/2026.04.17.719233
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00