Novel Type-I Carbazole/Benz[cd]indolium Photosensitizers for High-Efficient Chemo/Photodynamic/Immune Multimodal Therapy of Hypoxic Tumor
triggered immunogenic cell death (ICD) in cancer cells by enhancing oxidative stress, promoting dendritic cell (DC) maturation, and boosting T cell infiltration. Consequently, novel carbazole/benz[cd]indolium PSs, as low-oxygen-dependent type-I PSs, may show promise for chemo/photodynamic/immune multitherapy and warrant further preclinical investigation.
Authors
- Jiayang Cai (ORCID: https://orcid.org/0009-0008-4752-4035)
- Dongwei Liu (ORCID: https://orcid.org/0000-0002-0697-0548)
- Weiwei Gong (ORCID: https://orcid.org/0000-0001-5345-9382)
- Yingxue Chang
- Pengbo Wang
- Ke Xu
- Xiao Liu
- Tao Yang
- Dongliang Ji
- Kang Yuan
- Yangyang Jiang
- Yifan Ma
- Yong Ling (ORCID: https://orcid.org/0000-0002-3373-011X)
Institutions
- Target (United States) (US)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Kochi Medical School Hospital (JP)
- Second People's Hospital of NanTong (CN)
- Second Affiliated Hospital of Nantong University
Publication Details
- Journal
- Bioconjugate Chemistry
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.bioconjchem.6c00147
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Graduate Research and Innovation Projects of Jiangsu Province