The culpable interneurons in infant brain injury that could cause epilepsy

The culpable interneurons in infant brain injury that could cause epilepsy Professor of Pathology, Lee J. Martin, discusses the prevalence and treatment challenges associated with hypoxic-ischemic encephalopathy (HIE), and his research that aims to identify new treatment targets such as TDP43 to improve outcomes for affected infants. Hypoxic-ischemic encephalopathy (HIE) is a brain injury caused by a reduction in oxygen and blood supply; it is the leading cause of neurodevelopmental morbidity in term infants. In babies, HIE can result from placental insufficiency, asphyxia, and cardiac arrest. In 2019, the incidence of neonatal encephalopathy was 6.5 cases/100,000 population in high-income countries, ~20 cases/100,000 population in South Asia, and ~54 cases/100,000 population in Sub-Saharan Africa.