Mechanism of <scp>Terpinen‐4‐ol</scp> in Suppressing β‐Cell Dedifferentiation: Restoring Mitophagy and Alleviating Mitochondrial Calcium Overload via Parkin‐Mediated <scp>MCU</scp> Degradation
BACKGROUND AND OBJECTIVE: overload and impaired autophagy. This study investigated the effects of terpinen-4-ol (T4O) on β-cell dedifferentiation and mitochondrial autophagy, with an emphasis on the role of the Parkin/MCU signalling pathway. METHODS: regulation. The investigation of the mechanism of the Parkin/MCU signalling pathway involved co-immunoprecipitation (Co-IP), mass spectrometry (MS) and protein synthesis inhibition assays. RESULTS: accumulation, thereby protecting against T2DM-induced β-cell dedifferentiation. CONCLUSION: signalling and autophagy.
Authors
- Xiaoxia Hu (ORCID: https://orcid.org/0000-0002-2719-3805)
- He Li (ORCID: https://orcid.org/0000-0002-9470-7167)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Qianqian Guo
- Yanyan Zhang
- Xiangchun Shen (ORCID: https://orcid.org/0000-0002-4333-9106)
- Jun Bi
- Dezuo Bai
- Hongyu Chen
Institutions
- IE University (ES)
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Cixian People's Hospital (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1111/dom.70774
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China