Injectable Double-Cross-Linked Hydrogel Enhanced by Mg/Mn-Based Nanozymes for Photothermal Therapy and Immunomodulation in Periodontal Bone Resorption
ions for immunomodulation and osteogenesis. Importantly, GGCM enables a time-sequential regenerative therapeutic cascade comprising rapid periodontal pathogen elimination upon NIR irradiation, subsequent anti-inflammatory immunomodulation via M2 macrophage polarization, and continuous osteogenic promotion and alveolar bone resorption reduction. Collectively, this multifunction-integrated MPM NZ-enhanced double-cross-linked hydrogel exhibits promising potential for periodontal bone regeneration, positioning it as a highly attractive photothermal therapeutic strategy for periodontitis and even other complex infectious bone defects.
Authors
- Zhilang Xu (ORCID: https://orcid.org/0000-0002-0286-342X)
- Defu Li (ORCID: https://orcid.org/0000-0001-6466-4947)
- Yuhao Yuan (ORCID: https://orcid.org/0000-0003-2629-5954)
- Changdao Mu (ORCID: https://orcid.org/0000-0002-1673-1313)
- Qingsu Cheng (ORCID: https://orcid.org/0000-0001-6127-4046)
- Lun Yuan (ORCID: https://orcid.org/0009-0003-1464-1933)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Panyu Li (ORCID: https://orcid.org/0000-0002-4191-7275)
- L. Zeng (ORCID: https://orcid.org/0009-0008-1316-3892)
- Yandong Mu (ORCID: https://orcid.org/0000-0002-1829-6116)
Institutions
- Applied Science Private University (JO)
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- Stomatology Hospital (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- University of Wisconsin–Milwaukee (US)
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acsami.6c03273
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China