<scp>UNC45B</scp> Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia
-activated force. We established tamoxifen-inducible skeletal muscle-specific Unc45b knockout (Unc45b imKO) mice to investigate whether the muscle atrophy and weakness due to the loss of Unc45b impacts metabolism and behavior. We found that Unc45b imKO reduced muscle mass and force at a whole-body level, but did not influence systemic glucose tolerance, insulin sensitivity, or the respiratory exchange ratio. However, Unc45b imKO mice reduced the amount of deeper non-rapid eye movement sleep, locomotor activity, and body temperature during the sleep phase. We conclude that UNC45B is essential for maintaining fast-twitch muscle mass and muscle force. In addition, Unc45b deficiency-mediated muscle loss is also associated with bone fragility, decreased body temperature, and impaired sleep quality.
Authors
- Ryo Fujita (ORCID: https://orcid.org/0000-0002-8392-0122)
- Taiga Nagamune
- Sayaka Higo-Yamamoto
- Akiko Hashimoto‐Hachiya
- Satoru Ato (ORCID: https://orcid.org/0000-0002-0667-8790)
- Yuuki Imai (ORCID: https://orcid.org/0000-0002-6119-0034)
- Katsutaka Oishi (ORCID: https://orcid.org/0000-0002-4870-0837)
- Nao Tokuda
- Aoi Ikedo (ORCID: https://orcid.org/0009-0006-2927-6520)
- Kohei Kido (ORCID: https://orcid.org/0000-0003-0665-6572)
- Daiki Watanabe (ORCID: https://orcid.org/0000-0002-1278-3773)
- Riki Ogasawara (ORCID: https://orcid.org/0000-0002-2600-1613)
- Noriyuki Nagaoka (ORCID: https://orcid.org/0000-0002-3920-1278)
- Seiya Mizuno (ORCID: https://orcid.org/0000-0002-6740-5817)
- Saori Tada
- Takashi Yamada
- Taiga Mishima
- Satoru Takahashi
Institutions
- Hiroshima University (JP)
- Osaka University of Health and Sport Sciences (JP)
- Sapporo Medical University (JP)
- University of Tsukuba (JP)
- Tokyo University of Science (JP)
- Okayama University (JP)
- Health Sciences University of Hokkaido (JP)
- Nagoya Institute of Technology (JP)
- Sapporo University (JP)
- Hokkaido University (JP)
- Tsukuba Medical Center Hospital (JP)
- Ehime University (JP)
- Nippon Sport Science University (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Aging Cell
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1111/acel.70502
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science