Multi-Target Modulation of Metabolic and Steroidogenic Pathways by Cinnamomum burmannii and Myristica fragrans in Polycystic Ovary Syndrome: An Integrative Transcriptomics, Metabolomic, Pharmacoinformatics and Experimental Validation
exert multi-target effects on metabolic and steroidogenic pathways relevant to PCOS. This integrative study demonstrates that transcriptomics-guided network pharmacology combined with experimental validation can identify synergistic phytotherapeutic strategies for complex endocrine disorders.
Authors
- Dante Saksono Harbuwono (ORCID: https://orcid.org/0000-0002-6006-2719)
- Nurpudji Astuti Taslim (ORCID: https://orcid.org/0000-0003-1349-5367)
- Fahrul Nurkolis (ORCID: https://orcid.org/0000-0003-2151-0854)
- Raymond R. Tjandrawinata (ORCID: https://orcid.org/0000-0003-0461-9874)
- Taruna Ikrar (ORCID: https://orcid.org/0000-0002-8081-8528)
- Arifa Mustika (ORCID: https://orcid.org/0000-0001-6461-5782)
- Prof. Dr. Eighty Mardiyan Kurniawati
- Salmon Charles Siahaan
- Edwin Hadinata
- H Hendarto
- Wiskara Jatipradresthya
Institutions
- Atma Jaya Catholic University of Indonesia (ID)
- Universitas Gadjah Mada (ID)
- Sunan Kalijaga State Islamic University Yogyakarta (ID)
- Universitas Airlangga (ID)
- Universitas Ciputra (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Indonesian Orthopaedic Association (ID)
- University of Kuala Lumpur (MY)
- Hasanuddin University (ID)
Publication Details
- Journal
- Nutrients
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/nu18081305
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00