Mechanically sensitized hydrogel microspheres trigger membrane receptor switch for cartilage repair
experiments revealed that the interaction between OBNC microspheres and stem cells effectively repaired cartilage damage caused by osteoarthritis. The results of this study provide new insights into the application of mechanical properties in stem cell bioengineering.
Authors
- Qinzhe Jiang (ORCID: https://orcid.org/0009-0005-6865-8938)
- Deting Xue (ORCID: https://orcid.org/0000-0001-6388-2862)
- Shengjun Qian
- Yaping Zhuang (ORCID: https://orcid.org/0000-0002-9244-0454)
- Luhan Bao (ORCID: https://orcid.org/0000-0002-3194-2506)
- Zhaoming Ye (ORCID: https://orcid.org/0000-0001-5951-5840)
- Qihua Cao
- Lifeng Jiang (ORCID: https://orcid.org/0000-0001-9552-5616)
- Feng Lin (ORCID: https://orcid.org/0000-0003-1740-9032)
- Yiwen Xu
- Yongxiang Shi
- Xiaohua Yu
- Lei Xiang
- Zengjie Zhang
- Jiayu Chen
- Lufeng Yao
- Wenguo Cui
- Ning Zhang
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Ningbo No. 2 Hospital (CN)
- Molecular Devices (United Kingdom) (GB)
- Second Affiliated Hospital of Zhejiang University (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.03.017
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Shanghai Municipal Health and Family Planning Commission
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province
- Key Research and Development Program of Zhejiang Province