Accounting for Differences in Plasma Protein Binding between Fish and Humans for Supporting Environmental Risk Assessment of Pharmaceuticals Using the Fish Plasma Model
in fish versus humans and using rainbow trout as a conservative species in the FPM for modeling API availability and effects in fish.
Authors
- Alison Nimrod Perkins
- Tiina Sikanen (ORCID: https://orcid.org/0000-0002-0788-1301)
- Mirco Weil (ORCID: https://orcid.org/0000-0002-6097-3109)
- Rod W. Wilson (ORCID: https://orcid.org/0000-0001-8832-0065)
- Anja Coors (ORCID: https://orcid.org/0000-0002-9224-2917)
- Maciej Trznadel (ORCID: https://orcid.org/0000-0002-0499-3930)
- Siffreya Pedersen
- A Ross Brown
- Alec Bell
- Charles R. Tyler
- Michael Lee
- Tea LM Pihlaja
- Michael Mohutsky
Institutions
- University of Helsinki (FI)
- Eli Lilly (United States) (US)
- University of Exeter (GB)
- ECT Oekotoxikologie (Germany) (DE)
Publication Details
- Journal
- Environmental Science & Technology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.est.5c15513
- Primary Topic
- Pharmaceutical and Antibiotic Environmental Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Federation of Pharmaceutical Industries and Associations
- Innovative Medicines Initiative
- Horizon 2020