Design, Synthesis, and Biological Evaluation of Methoxy-Substituted Chalcones and Gypsogenin-Based Hybrids as Anticancer and Antimicrobial Agents
) were performed to explore potential interactions with key cancer-related targets. Overall, the results highlight the chalcone scaffold as the main contributor to biological activity in this series and demonstrate that hybridization with gypsogenin did not enhance the cytotoxic potency.
Authors
- Nafia Gökçe Ulusoy (ORCID: https://orcid.org/0000-0001-6604-7838)
- Nuran Kahriman (ORCID: https://orcid.org/0000-0001-9729-433X)
- Vildan Serdaroğlu (ORCID: https://orcid.org/0000-0002-0487-1597)
- Burçin Türkmenoğlu (ORCID: https://orcid.org/0000-0002-5770-0847)
- Safiye Emirdağ
- Fatma Demir (ORCID: https://orcid.org/0000-0002-6130-0694)
- Nurettin Yaylı
Institutions
- Karadeniz Technical University (TR)
- Erzincan Binali Yıldırım University (TR)
- Ege University (TR)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acsomega.5c13679
- Primary Topic
- Synthesis of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ege Üniversitesi
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu