Structure-Function Analysis of the FCRL5-IgG1 Fc Complex Reveals an Unappreciated Effect of Fc-Silent Antibodies on B cells
flux in FCRL5-expressing B cells. We compare this effect with the selective co-ligation of FcγRIIb with the BCR. Our work demonstrates that FCRL5 interacts with human IgG Fc in a distinctive manner and that engagement of FCRL5 by Fc-silent therapeutic IgG could influence B cell function.
Authors
- George Delidakis (ORCID: https://orcid.org/0000-0002-4330-9476)
- Bart M. Herpers
- Jin Eyun Kim (ORCID: https://orcid.org/0000-0002-6297-3292)
- Sanghwan Ko (ORCID: https://orcid.org/0000-0002-2950-4937)
- Mo Guo (ORCID: https://orcid.org/0009-0000-9103-975X)
- Mohamed I Gadallah
- Jennifer S Brodbelt
- George Georgiou
- Y Jessie Zhang
- Chang-Han Lee
Institutions
- The University of Texas at Austin (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-21
- DOI
- https://doi.org/10.64898/2026.04.16.718972
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- Welch Foundation
- National Institutes of Health
- Office of Science
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- Argonne National Laboratory