Physical stability of salbutamol amorphous solid dispersion tablets measured by terahertz spectroscopy
is consistent over time and agrees with that of the salbutamol ASDs, whilst distinctively differentiating the pharmaceutical tablets from crystalline salbutamol. The direct, rapid, and non-destructive assessment of crystallinity, particularly via the simple, physically interpretable absorption coefficient ratio, makes THz-TDS advantageous for longitudinal stability studies and individual tracking of solid dosage forms during drug product development.
Authors
- Andreas Kottlan (ORCID: https://orcid.org/0000-0001-7196-5326)
- Chi Ki Leung (ORCID: https://orcid.org/0000-0002-0399-2784)
- Lisa Kuchler
- J. Axel Zeitler (ORCID: https://orcid.org/0000-0002-4958-0582)
Institutions
- University of Cambridge (GB)
- Université Bourgogne Franche-Comté (FR)
- Research Center Pharmaceutical Engineering (Austria) (AT)
Publication Details
- Journal
- International Journal of Pharmaceutics
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1016/j.ijpharm.2026.126903
- Primary Topic
- Terahertz technology and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Österreichische Forschungsförderungsgesellschaft