Loss of SHP-1 in CD11c+ cells impairs anti-tumor immunity
Background: cells on the anti-tumoral response. Methods: mice, respectively. Tumor growth and survival were monitored, and immune infiltrates were analyzed using flow cytometry or scRNA-seq. Results: littermates. Conclusions: cells impairs anti-tumor immunity and suggest that both cDC1s and macrophages contribute to this effect.
Authors
- Elena Hernández‐García (ORCID: https://orcid.org/0000-0002-9018-5701)
- Jon Sicilia (ORCID: https://orcid.org/0000-0002-5073-9132)
- Miguel Galán
- Sergio Callejas Alejano
- Ana Dopazo (ORCID: https://orcid.org/0000-0002-4910-1684)
- David Sancho (ORCID: https://orcid.org/0000-0003-2890-3984)
- M. Ascensión Rey-Martín
- Ana Redondo‐Urzainqui (ORCID: https://orcid.org/0000-0002-5551-4418)
- Francisco J. Cueto (ORCID: https://orcid.org/0000-0002-7457-9583)
- Salvador Iborra (ORCID: https://orcid.org/0000-0002-1607-1749)
- Pablo Munné
Institutions
- Universidad Complutense de Madrid (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Inmunotek (Spain) (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3389/fimmu.2026.1710547
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Estatal de Investigación