Metabolic and Genetic Alterations in Early and Exudative Age-Related Macular Degeneration: Inosine, Amino Acids, and COL2A1 Gene Variant
rs1635529 polymorphism showed a nominal association with early AMD, but not exudative AMD. Differences in leucine and inosine levels were observed, suggesting a potential link between genetic variation and metabolic alterations. These findings indicate possible involvement of collagen-related and metabolic pathways in early disease development; however, the results should be interpreted with caution and require validation in larger studies.
Authors
- Rasa Liutkevičienė (ORCID: https://orcid.org/0000-0001-5395-923X)
- Alvita Vilkevičiūtė (ORCID: https://orcid.org/0000-0002-0427-5568)
- Ieva Čiapienė (ORCID: https://orcid.org/0009-0004-3393-1474)
- Džastina Čebatorienė
- Akvile Bruzaite (ORCID: https://orcid.org/0009-0005-6654-8575)
- Dalia Žaliūnienė (ORCID: https://orcid.org/0000-0002-4800-7629)
- Alina Smalinskienė (ORCID: https://orcid.org/0000-0001-8816-3995)
- Loresa Kriauciuniene
Institutions
- Lithuanian University of Health Sciences (LT)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/ijms27083697
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lietuvos Mokslo Taryba
- Lietuvos Sveikatos Mokslų Universitetas