Quality and Readability of Large Language Models' Responses to Oral Lichen Planus Patients' <scp>FAQs</scp>

OBJECTIVE: To evaluate the quality and readability of large language models (LLMs) when responding to Frequently Asked Questions (FAQs) about oral lichen planus (OLP). METHODS: We evaluated the responses of three LLMs (ChatGPT-4o, Gemini 2.0 Flash Experimental, and Copilot) to 13 patient-centered FAQs about OLP. Questions were identified using query tools, and answers were assessed by 14 oral medicine experts using the Quality Assessment of Medical Artificial Intelligence (QAMAI) tool. Readability was analyzed with the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKG) tools. RESULTS: All LLMs provided generally accurate and relevant responses, with median QAMAI scores indicating "good" to "very good" quality. ChatGPT achieved slightly higher completeness, particularly for questions on OLP definition and treatment. The reference provision was inconsistent across all chatbots. Readability analysis revealed that most responses required college-level literacy, with ChatGPT producing the most complex texts, Gemini occasionally achieving more accessible outputs, and Copilot situated in an intermediate position. CONCLUSIONS: LLMs may have potential as adjunctive tools for patient education in OLP, although they remain limited by incomplete information, inconsistent references, and suboptimal readability. Future research should incorporate longitudinal LLMs evaluations and training to develop models delivering accurate, accessible information, tailored to users' literacy levels.

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Publication Details

Journal
Oral Diseases
Published
2026-04-20
DOI
https://doi.org/10.1111/odi.70334
Primary Topic
Health Literacy and Information Accessibility
Type
article
Field-Weighted Citation Impact
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article

Quality and Readability of Large Language Models' Responses to Oral Lichen Planus Patients' FAQs

Caroline Bissonnette, Arwa M. Farag, Alessandro Polizzi, Alan Roger Santos‐Silva et al.
Oral Diseases
Health Literacy and Information Accessibility
article

Quality and Readability of Large Language Models' Responses to Oral Lichen Planus Patients' FAQs

Caroline Bissonnette, Arwa M. Farag, Alessandro Polizzi, Alan Roger Santos‐Silva, Rosa María López‐Pintor, Jairo Robledo Sierra, Vito Carlo Alberto Caponio, Gaetano Isola, Vlaho Brailo, Paswach Wiriyakijja, G Hernández, María Pía López Jornet, Thomas P. Sollecito, H X Dan, Marcio Diniz Freitas, Rui Albuquerque, José González‐Serrano
article en

Abstract

OBJECTIVE: To evaluate the quality and readability of large language models (LLMs) when responding to Frequently Asked Questions (FAQs) about oral lichen planus (OLP). METHODS: We evaluated the responses of three LLMs (ChatGPT-4o, Gemini 2.0 Flash Experimental, and Copilot) to 13 patient-centered FAQs about OLP. Questions were identified using query tools, and answers were assessed by 14 oral medicine experts using the Quality Assessment of Medical Artificial Intelligence (QAMAI) tool. Readability was analyzed with the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKG) tools. RESULTS: All LLMs provided generally accurate and relevant responses, with median QAMAI scores indicating "good" to "very good" quality. ChatGPT achieved slightly higher completeness, particularly for questions on OLP definition and treatment. The reference provision was inconsistent across all chatbots. Readability analysis revealed that most responses required college-level literacy, with ChatGPT producing the most complex texts, Gemini occasionally achieving more accessible outputs, and Copilot situated in an intermediate position. CONCLUSIONS: LLMs may have potential as adjunctive tools for patient education in OLP, although they remain limited by incomplete information, inconsistent references, and suboptimal readability. Future research should incorporate longitudinal LLMs evaluations and training to develop models delivering accurate, accessible information, tailored to users' literacy levels.

Oral Diseases
Universidad Complutense de Madrid (ES), Tufts University (US), University Hospital Centre Zagreb (HR), Chulalongkorn University (TH), Universidade Estadual de Campinas (UNICAMP) (BR), Guy's and St Thomas' NHS Foundation Trust (GB), Universidade de Santiago de Compostela (ES), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Sichuan University (CN), University of Catania (IT), Hospital General Universitario Morales Meseguer (ES), King Abdul Aziz University Hospital (SA), Universidad CES (CO), Link Campus University (IT), Université de Montréal (CA), University of Pennsylvania (US), University of Gothenburg (SE)
Instituto de Salud Carlos III
Quality Education
Openalex Percentile: Top 14%
Health Literacy and Information Accessibility
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