Outcome of preterm newborns admitted with respiratory distress in relation to time of initiation of CPAP

= 3.218, p = 0.073). After adjustment for gestational age and disease severity, early CPAP initiation was independently associated with lower odds of mortality (aOR = 0.34, 95% CI: 0.13-0.89, p = 0.027). Median CPAP duration was significantly longer in the early CPAP group (48.0 vs 24.0 h; p = 0.027). Length of hospital stay was also significantly longer (14 vs 8 days; p = 0.014), while mechanical ventilation duration did not differ significantly (p = 0.140).ConclusionEarly CPAP initiation in preterm newborns with respiratory distress was associated with lower mortality after adjustment for gestational age and disease severity, although the unadjusted analysis was not statistically significant. These findings suggest a potential benefit of early CPAP initiation in resource-limited settings.