Reprogramming viral entry for precision therapeutics

Reprogramming viral entry for precision therapeutics Here, Cedars-Sinai Medical Center synthesize foundational adenovirus biology with key advances to present a unified model of penton base structure, function, and translational reprogramming. Efficient intracellular delivery – specifically escape from the endosomal compartment into the cytosol – remains one of the most formidable challenges in nucleic acid and macromolecular therapeutics.1 Viruses solve this problem through evolutionarily refined mechanisms that integrate receptor targeting, intracellular trafficking, and membrane disruption.2 Among these viral solutions, the adenovirus penton base stands out as a structurally discrete yet biologically powerful capsid protein that orchestrates internalization and endosomal escape.