Copper-Catalyzed Cascade Coupling/Cyclization/Switchable aza-Claisen Rearrangement for Indole Skeletons
-allyl-2 alkynylanilines and diazo compounds. Compared to previous works, the application of diazo compounds as coupling partners significantly expanded the variety of functional groups on the C2 position. Importantly, a catalytic amount of organic base, triethylamine, was found to act as a chemical switch to govern two different aza-Claisen rearrangement pathways.
Authors
- Tiebo Xiao (ORCID: https://orcid.org/0000-0003-0799-1049)
- Junyu Chen (ORCID: https://orcid.org/0009-0004-4657-1850)
- Ping Wang
Institutions
- Kunming University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.orglett.6c01125
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China