A Deep-Red-Absorbing Osmium(II)-Based Photosensitizer Evokes Pyroptosis by Targeting Glutamine Metabolism and Impairing Cell Redox Homeostasis
to gasdermin D (GSDMD)-mediated pyroptosis. Our study offers a new avenue for the development of scalable pyroptosis-inducing agents.
Authors
- Philippe Arnoux (ORCID: https://orcid.org/0000-0002-6834-9597)
- Bruno Saubaméa (ORCID: https://orcid.org/0000-0002-6218-0460)
- Gilles Gasser (ORCID: https://orcid.org/0000-0002-4244-5097)
- Céline Frochot (ORCID: https://orcid.org/0000-0002-7659-3864)
- James W. Southwell (ORCID: https://orcid.org/0000-0003-3219-1326)
- Pierre Mesdom (ORCID: https://orcid.org/0000-0003-1069-2138)
- Zhimei Xiao
- Ruonan Gao
- Morgane Moinard
- Yiyi Zhang
Institutions
- Centre National de la Recherche Scientifique (FR)
- Chimie ParisTech - PSL (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Laboratoire Réactions et Génie des Procédés (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/jacs.6c04446
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- China Scholarship Council
- European Research Council