Tailoring Avidity through Morphology: Structure−Avidity Relationship in CD38-Binding Nanofiber Radiotracers
Cu, exhibit exceptional serum stability, and show no toxicity at doses 20-fold above projected imaging use. By establishing lipid tail length as a simple, powerful handle for controlling nanofiber structure, avidity, and function, we present a robust, translatable platform for advancing targeted imaging and therapy in CD38-positive malignancies.
Authors
- Jacqueline M. Godbe (ORCID: https://orcid.org/0000-0002-8769-2083)
- Monica Shokeen (ORCID: https://orcid.org/0000-0001-8114-9584)
- Hongwei Zhang (ORCID: https://orcid.org/0000-0001-8838-7753)
- Julie L. Prior (ORCID: https://orcid.org/0009-0009-0292-1552)
- Michael Riley Dyer (ORCID: https://orcid.org/0009-0006-4824-5076)
- Zhenghan Jing
- Katelyn N. Ernst
- Erin Teubner
- Amit K. Sharma
- Yang Yang
- Rui Tang (ORCID: https://orcid.org/0000-0002-2734-1003)
- Brad Manion
Institutions
- Barnes-Jewish Hospital (US)
- Van Andel Institute (US)
- Washington University in St. Louis (US)
- Jewish Hospital (US)
- Alvin J. Siteman Cancer Center (US)
- Mallinckrodt (Ireland) (IE)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acsabm.6c00348
- Primary Topic
- Supramolecular Self-Assembly in Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radiological Society of North America
- National Cancer Institute