Palladium-Catalyzed Oxidative Carbonylative Carbocyclization of Enallenes: Highly Regio- and Stereoselective Allenylic C(sp <sup>3</sup> )–H Activation to 5-Methylene Cyclopentenone
)-H activation, and ligand control enables site-selective transformation of unsymmetrical enallenes, favoring the larger alkyl substituent over methyl (up to 20:1). A broad substrate scope and compatibility with heterogeneous Pd-AmP-MCF catalysis and biomimetic aerobic oxidation underscore the practicality and sustainability of the method.
Authors
- Xin Mu (ORCID: https://orcid.org/0000-0002-1514-3210)
- Bolin Wang (ORCID: https://orcid.org/0000-0002-1477-4950)
- Nasır Iqbal (ORCID: https://orcid.org/0000-0003-1133-8229)
- Yi Ren (ORCID: https://orcid.org/0000-0001-8027-8851)
- Jan‐E. Bäckvall (ORCID: https://orcid.org/0000-0001-8462-4176)
- Bin Yang (ORCID: https://orcid.org/0009-0002-7397-9320)
- Muhammad Junaid
- Gohar Abbas
- Saqib Javed
- Haoge Qian
Institutions
- Stockholm University (SE)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.orglett.6c01300
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Xi’an Jiaotong University
- Ministry of Science and Technology of the People's Republic of China
- Knut och Alice Wallenbergs Stiftelse
- Stiftelsen Olle Engkvist Byggmästare
- Vetenskapsrådet