Severe numbness of the mouth and tongue induced by piperacillin/tazobactam: a rare case report
BACKGROUND: Severe oral and tongue numbness induced by piperacillin/tazobactam is extremely rare. RESULTS: A 58-year-old man with bacterial pneumonia developed oral and tongue numbness, dyspnea, and pruritus approximately 4 minutes after intravenous infusion of piperacillin/tazobactam. Based on adverse drug reaction causality assessment, this event was identified as a previously unreported severe adverse drug reaction. DISCUSSION: This case suggests that during clinical use of piperacillin/tazobactam, clinicians should remain vigilant for rare but severe adverse drug reactions even when skin testing is negative, and strengthen medication monitoring to ensure medication safety.
Authors
- 実 立川
- Yi Li (ORCID: https://orcid.org/0009-0002-4763-0811)
- Wanlin Liu (ORCID: https://orcid.org/0009-0005-0361-001X)
- Bo Tan (ORCID: https://orcid.org/0009-0008-6470-3748)
- Liutao Zheng (ORCID: https://orcid.org/0009-0008-0369-8906)
- Nianqing Yin (ORCID: https://orcid.org/0009-0005-1024-9808)
- Yanli Dai (ORCID: https://orcid.org/0009-0002-4177-0469)
Institutions
- Jingzhou Maternal and Child Health Hospital (CN)
- People's Hospital of Cangzhou (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Future Science OA
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1080/20565623.2026.2653792
- Citations
- 1
- Primary Topic
- Oral and gingival health research
- Type
- article
- Field-Weighted Citation Impact
- 47.66