Combination Gene Therapy with AAV-Based Vectors Ameliorates the Phenotype of Type 2 Diabetes in Diet-Induced Obese and db/db Mice
mice without any adverse effects on skeletal muscles. These findings support the use of optimized AAV8 human codon-optimized FGF21 as a viable, long-lasting therapeutic strategy for T2DM.
Authors
- Ramkumar Rajendiran
- Subhajit Pathak (ORCID: https://orcid.org/0000-0001-9118-0622)
- Giridhara R. Jayandharan (ORCID: https://orcid.org/0000-0001-9353-9053)
- Sai Prasad Pydi
- Soumita Bhaumik
- Sonal Amit
- Ashish Kumar
Institutions
- Ganesh Shankar Vidyarthi Memorial Medical College (IN)
- Bio-Medical Science (South Korea) (KR)
Publication Details
- Journal
- Molecular Pharmaceutics
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.molpharmaceut.5c01896
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Institute of Technology Kanpur
- Council of Scientific and Industrial Research, India
- Science and Engineering Research Board